Screening procedure (Total 974481 Papers Found)

OBJECTIVE To identify those women who might benefit from oestrogen replacement after hysterectomy. DESIGN Targeted health screening. SETTING Large group practice. SUBJECTS All women aged under 50 who had had a hysterectomy. MAIN OUTCOME MEASURES Concentration of follicle stimulating hormone, symptom profile, uptake of oestrogen replacement therapy. RESULTS 145 of 1953 women aged 32-49 had had a hysterectomy. 35 of the 41 with bilateral oophorectomy and 27 of 104 with one or more ovarie ...
Cardiovascular disease remains common and accounts for many deaths, but primary cardiovascular risk factors are consistently underdiagnosed in the UK. NHS health checks are being implemented nationally in the next five years, targeting those aged 40 to 74 years, and many primary care trusts have commissioned health checks to be carried out opportunistically as an outreach programme in public places to aid uptake and improve access. However, there is little published evidence on the effectiveness ...
BACKGROUND In a randomized controlled study aiming to test the effectiveness of preimplantation genetic screening (PGS) in women of advanced maternal age, embryos diagnosed as chromosomally abnormal and those with no diagnosis were fixed for reanalysis. The aim of this study was to determine how well the chromosomal constitution of one biopsied blastomere reflects the status of the entire embryo. METHODS One hundred and seventy-three embryos diagnosed as chromosomally abnormal, 22 with no PGS ...
In October 2015, the American Cancer Society (ACS) updated its evidence-based breast cancer screening guidelines for women at average risk for breast cancer. These guidelines introduced significant changes to the age to begin breast cancer screening, as well as the frequency between screenings and duration of screening. Not long afterward, in January 2016, the U.S. Preventive Services Task Force released its updated breast cancer screening guidelines, which differ from those of the ACS. The vary ...
BACKGROUND Darrier's disease is a rare genodermatosis with a dominant autosomic penetrating variable transmission. The association between Darier's disease and neuropsychiatric disorders has been reported since 1996. Moreover, associations with mental retardation, schizophrenia, mood disorders and suicide have been reported. The discovery in 1999 of the ATP2A2 gene of Darier's disease, localised on chromosome 12, allowed significant advances notably in understanding the pathogenicity of these sy ...
Repetitive tympanometric screenings were performed in 79 randomized, otherwise healthy children from 2 to 7 years old. A total of nine screenings, of which three included otomicroscopy, were performed. When the children were 7 years of age, radiographs were made of their mastoid processes in Runstrøm's lateral projection. The median size of the cell system was 8.25 cm2. The cell systems were significantly larger (9 cm2) in girls than in boys (7.5 cm2). A significant correlation was found betwee ...
The current medical system provides medical services to patients who visit hospitals. However, medical services can be provided at or close to the home of the patient using fully-equipped mobile telemedicine systems. Such a system can identify diseases at an early stage, improve the patient's quality of life and prognosis through early diagnosis and treatment, and reduce the cost of the medical service. Furthermore, the unit can provide mass screenings of the population, as well as a full medica ...
A glucose challenge test (GCT) was developed as a screening procedure for the diagnosis of gestational diabetes mellitus (GDM). The method includes a 50gm oral glucose load and measurement of the plasma glucose concentration once at one hour after ingestion. The data were examined in 1,184 pregnant women seen at the outpatient clinic of our department from May 1984 to December 1986. Prior to the present study, 722 pregnant women were given a 75gm glucose tolerance test (75gGTT) and plasma glucos ...
BACKGROUND We implemented a community based interventional health screening for individuals located within one mile of a 54 metric tons release of liquid chlorine following a 16 tanker car train derailment on 6 January, 2005 in Graniteville, South Carolina, USA. Public health intervention occurred 8-10 months after the event, and provided pulmonary function and mental health assessment by primary care providers. Its purpose was to evaluate those exposed to chlorine for evidence of ongoing impair ...
BACKGROUND Group II introns are RNA enzymes that splice themselves from pre-mRNA transcripts. Most bacterial group II introns harbour an open reading frame (ORF), coding for a protein with reverse transcriptase, maturase and occasionally DNA binding and endonuclease activities. Some ORF-containing group II introns were shown to be mobile retroelements that invade new DNA target sites. From an evolutionary perspective, group II introns are hypothesized to be the ancestors of the spliceosome-depen ...
The recent debate on preimplantation genetic screening (PGS) has raised questions about its routine use in clinical practice. It has been suggested that the most effective way to resolve the debate about the usefulness of PGS is to perform more well-designed and well-executed randomized controlled trials (RCTs). However, in view of the lack of evidence for the effectiveness of PGS and the accumulating evidence for its harmfulness, it is our opinion that it is unethical to perform additional RCTs ...
OBJECTIVE To determine the appropriate body mass index (BMI) and waist circumference (WC) cutoff point for identification of at least one cardiovascular risk factor (hypertension, dyslipidemia, and type 2 diabetes) in Thailand, and to compare the discrimination ability of BMI with that of WC for discrimination of at least one cardiovascular risk factor. MATERIAL AND METHOD Baseline health survey data of participants of Thai Epidemiologic Stroke (TES) Study, who were free from stroke, enrolled ...
The direct link between socioeconomic status (SES) and health outcomes is well known, especially for non-communicable diseases such as diabetes, hypertension, and mental disorders. We read the article titled “Disparity in Health Screening and Health Utilization according to Economic Status” by Kim et al., published in the July 2017 issue of the Korean Journal of Family Medicine. Kim et al. showed a correlation between lower economic status and lower rate of health screening attendance and po ...
BACKGROUND Roughly 21% of youth in the United States meet criteria for a mental health diagnosis, but only one-fifth of those children obtain help. The Pediatric Behavioral Health Screen (PBHS) utilizes the Pediatric Symptom Checklist-17 (PSC-17) and functional impairment items to assess behavioral health concerns. METHODS Data were obtained from a systematic chart review for children 6 to 16 years old. Descriptive analyses and a confirmatory factor analysis were used to evaluate the clinical ...
OBJECTIVE To determine the validity of the neck extension-rotation test as a clinical screening procedure to detect decreased vertebrobasilar blood flow that might be associated with dizziness. DESIGN Secondary analysis of a clinical screening test. METHODS Twelve subjects with dizziness reproduced by the extension-rotation test and 30 healthy control subjects had Doppler ultrasonography examination of their vertebral arteries with the neck extended and rotated. Vascular impedance to blood f ...
Platelets metabolize arachidonic acid to thromboxane A2, a potent platelet aggregator and vasoconstrictor compound. The first step of this transformation is catalyzed by prostaglandin (PG) G/H synthase, a target site for nonsteroidal antiinflammatory drugs. We have isolated the cDNA for both human platelet and human erythroleukemia cell PGG/H synthase using the polymerase chain reaction and conventional screening procedures. The cDNA encoding the full-length protein was expressed in COS-M6 cells ...
Epidemiological research points to the high prevalence of psychiatric disorders among insomniacs. We carried out a cross-sectional study with medical students with the aim of evaluating the association between insomnia and suspicion of psychiatric disorder; 302 medical students were included (184 males and 118 females; mean age = 20.47+/-1.89 years). The main association was tested by logistic regression analysis. The overall prevalence of positivity in a screening test for psychiatric disorder ...
The authors conducted a pilot study to identify patients at risk for developing cardiovascular disease and to see if the community pharmacy is an appropriate site for identifying patients with hypercholesterolemia. Free cholesterol screenings were advertised in newspapers and in the pharmacy. Patients obtained an appointment time for the screening by calling an 800 number and were interviewed for risk factors associated with coronary heart disease. Of the 539 patients enrolled in the study, 78% ...
Senescence is a mechanism that limits cellular lifespan and constitutes a barrier against cellular immortalization. To identify new senescence regulatory genes that might play a role in tumorigenesis, we have designed and performed a large-scale antisense-based genetic screen in primary mouse embryo fibroblasts (MEFs). Out of this screen, we have identified five different genes through which loss of function partially bypasses senescence. These genes belong to very different biochemical families ...
Permanent stop-and-shop large-scale mouse mutant resources provide an excellent platform to decipher tissue phenogenomics. Here we analyse skin from 538 knockout mouse mutants generated by the Sanger Institute Mouse Genetics Project. We optimize immunolabelling of tail epidermal wholemounts to allow systematic annotation of hair follicle, sebaceous gland and interfollicular epidermal abnormalities using ontology terms from the Mammalian Phenotype Ontology. Of the 50 mutants with an epidermal phe ...
A sensitized genetic screen was carried out to identify essential genes involved in silencing in Succharv myces cereuisiae. This screen identified temperature-sensitive alleles of ORC2 and ORC5, as described elsewhere, and ABFl, NPLS, and YCL54, as described here. Alleles of ABFl that caused silencing defects provided the genetic proof of Abflp’s role in silencing. The roles of Npl3p and Yc154p are less clear. These proteins did not act exclusively through any one of the three protein binding ...
AIM to describe the expectations to and knowledge of antenatal screening of expecting parents, and their experiences concerning the first-trimester screening scan. DESIGN survey study with a consecutive sampling method. SETTING two hospital districts in Finland, namely the capital area and Eastern Finland. Together these two districts include the six different municipal units in which the first-trimester screening scans discussed in the study were done during spring 2015. PARTICIPANTS 1037 ...
OBJECTIVES To describe the uptake and outcomes of a service for tuberculosis screening of asylum seekers. STUDY DESIGN Descriptive study. METHODS A tuberculosis screening service was established at the Dover Induction Centres for all asylum seekers entering the UK through ports in Kent. This study describes the uptake and completion of tuberculosis screening, the results of tuberculin skin testing and follow-up, and the cost of the service during its first year. RESULTS In 1 year, 8258 asy ...
Sexual minority women may be at higher risk of breast, cervical, and colorectal cancer compared to heterosexual women. In addition, sexual minority women may use preventive cancer-related screening services less than heterosexual women. Using a population-based probability sample of Missouri women, we compared cancer screening behavior of heterosexual (n=29,847), self-identified lesbian (n=114), and bisexual (n=162) women. Sexual minority women were significantly younger by approximately 10 year ...
As the letter has pointed out, there are quite a few differences in patient background between the two patient groups, i.e., those previously screened by X-ray and those directly screened by endoscopy. If the paper in question attempts to compare the diagnostic accuracy between X-ray and endoscopic screenings, the above differences are critical. Nevertheless, the thread of the story is different. It is understandable that the cancer detection rate in the group that underwent two screening proced ...
Introduction of conditional murine p53 (p53val135) and oncogenic ras into double p53/p21-null mouse embryonic fibroblasts (MEFs) showed that p21waf1 was not required for combined ras/p53-induced senescent-like growth arrest. We used this cellular system to identify key players in the ras-p53-induced senescence in the absence of p21. Applying a retroviral-based genetic screen, we obtained mRNA antisense fragments against a cluster of 14 different ribosomal proteins which loss of function bypasses ...
Cell-derived vesicles in particular extracellular vesicles (EVs) such as microparticles (MPs) and microvesicles besides exosomes are raising more and more attention as a novel and unique approach to detect diseases. It has recently become apparent that disease specific MP signatures or profiles might be beneficial to differentiate chronic liver diseases such as non-alcoholic fatty liver disease and chronic hepatitis C, to monitor their progression or possibly to assess treatment outcome. Therefo ...
Familial hypercholesterolemia (FH) is a common inherited disorder that results in premature atherosclerosis. Diagnosis of FH is suspected on the basis of clinical criteria, but confirmation requires genetic testing. In the era of statins, early diagnosis and initiation of treatment can modify disease progression and outcomes. Therefore, cascade screening with a combination of lipid concentration measurements and DNA testing should be used to identify relatives of index cases with a clinical diag ...
A very good friend of mine, aged 54 yr, has recently lived through the unpleasant experience of an elevated prostatespecific antigen (PSA), a prostate biopsy, and, ultimately, the diagnosis of a Gleason 7 bilateral prostate cancer. He decided to have radical prostatectomy, and after 4 mo, he is doing fine but has weak erections. When talking about his disease and the bad times he had, he repeatedly insisted that what he lacked the most from his surgeon was ‘‘compassion.’’ He was well inf ...
AIMS AND BACKGROUND Mucinous adenocarcinoma (MA) colorectal cancer accounts for 10 to 15% of colorectal carcinoma. It is generally thought that patients with MA present at a more advanced stage of disease and have a poorer prognosis than those with other types of carcinoma. The purpose of the present study was to clarify the clinicopathological characteristics of mucinous colorectal carcinoma in the Iranian population. METHODS Between January 2002 and March 2008, Of the 1283 colorectal cancer ...
Phosphorylation by kinases is an important post-translational modification of proteins. It is a critical control for the regulation of vital cellular activities, and its dysregulation is implicated in several diseases. A common drug discovery approach involves, therefore, time-consuming screenings of large libraries of candidate compounds to identify novel inhibitors of protein kinases. In this work, we propose a novel method that combines localized surface plasmon resonance (LSPR) and electroly ...
The clinical usefulness of sputum cultures depends on the quality of specimens submitted to the laboratory. In a community hospital, during two separate surveillance periods, we evaluated ordering practices and circumstances under which sputum specimens were obtained and techniques to improve the quality of the specimens. Physicians themselves rarely participated in obtaining specimens of sputum, and members of the nursing staff directly instructed patients or supervised specimen collection in o ...
Medullary thyroid carcinoma occurs sporadically or as a part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. The MEN 2 gene has been identified as the RET proto-oncogene on chromosome 10. In MEN 2A, RET mutations are detectable in one of five cysteine codons within exons 10 and 11 and in MEN 2B in codon 918 (exon 16). Direct DNA testing for RET proto-oncogene mutations is the method of first choice in presymptomatic screening of MEN 2 families. Gene carriers should be ...
Neuroendocrine tumors (NETs) can be sporadic or they can arise in complex hereditary syndromes. Patients with hereditary NETs can be identified before the development of tumors by performing genetic screenings. The aim of the study was to evaluate the clinical and prognostic impact of a preclinical genetic screening in subjects with hereditary NET syndromes. 46 subjects referred for hereditary NET syndrome [22 MEN1, 12 MEN2, 12 Familial Paragangliomatosis (FPGL)] were enrolled and divided in 2 g ...
Serum levels of uric acid (UA) are associated with metabolic syndrome (MetS). However, no study has been aimed to investigate whether baseline UA is a predictor of MetS in a Japanese population. The multivariable adjusted hazard ratios (HRs) of MetS through 3 years were calculated for each 1 SD increase in baseline UA, for the higher quartiles of baseline UA compared with the lowest quartile, and for baseline hyperuricemia defined as ≥7.0 mg/dl for men and ≥6.0 mg/dl for women in apparent ...
PURPOSE To conduct a needs assessment to determine employee attitudes and barriers toward participation in a multidisciplinary work site-based health and wellness clinic. METHODS A 21-question survey was developed and sent electronically to all available (n = 874) employees of a self-insured employer. RESULTS Of the 303 survey respondents (34.7% response rate), 67.3% (n = 204) individuals indicated a desire to meet with a pharmacist regarding medication information. Medication therapy manage ...
Beta-lactamase inhibitory protein (BLIP) binds and inhibits a diverse collection of class A beta-lactamases with a wide range of affinities. Alanine-scanning mutagenesis was previously performed to identify the amino acid sequence requirements of BLIP for binding the TEM-1, SME-1, SHV-1, and Bla1 beta-lactamases. Twenty-three BLIP residues that contact TEM-1 beta-lactamase in the structure of the complex were mutated to alanine and assayed for inhibition (K(i)) of beta-lactamase to identify two ...
OBJECTIVE Despite increased interest in screening adolescents for mental health problems and suicide risk, little is known regarding the extent to which youth are identified and connected with appropriate services. METHOD Between 2005 and 2009, a total of 4,509 ninth-grade students were offered screening. We reviewed the records of the 2,488 students who were screened. Students identified as being at risk were provided with a referral. Data were collected on screening results, mental health re ...
BACKGROUND & OBJECTIVE In order to improve early detection and visualization of esophageal premalignant lesion and carcinoma, this study was designed to explore significance of the screening by iodine staining of endoscopic examination in the area of high incidence of esophageal carcinoma. METHODS Three screenings were completed through endoscopic examination for 3164 persons in high-risk population. Esophageal epithelium was stained with iodine in endoscopic examination. According to mucosal ...
A common clinical situation is finding abnormal liver enzymes on a biochemical profile. In some cases abnormal liver enzymes are first identified in the clinically normal patient on a routine health screen or as a preanesthetic screen prior to an elective surgery. Froe frequently abnormal liver enzymes are identified in sick patients as part of a complete diagnostic work-up. Some of those sick patients may have primary liver disease but most usually have some other primary disorder with a so-cal ...
Several key components of the RNA interference (RNAi) pathway were identified in genetic screens performed in non-mammalian model organisms. To identify components of the mammalian RNAi pathway, we developed a recessive genetic screen in mouse embryonic stem (ES) cells. Recessive genetic screens are feasible in ES cells that are Bloom-syndrome protein deficient (Blm-deficient). We constructed a reporter cell line in Blm-deficient ES cells to isolate RNAi mutants using a simple drug selection sch ...
PURPOSE This article describes the health testing training process used at Presbyterian College School of Pharmacy and evaluates perceptions of the sequential training model among students in their first, second, and third professional years. EDUCATIONAL ACTIVITY AND SETTING After observing student deficiencies in the knowledge and skills necessary for performing health tests, despite receiving didactic training within the core curriculum, faculty members searched for supplemental training pro ...
Purpose Our aim was to determine the role of end-of-induction (EOI) minimal residual disease (MRD) assessment in the identification and stratification of induction failure in patients with pediatric acute lymphoblastic leukemia (ALL) and to identify genetic abnormalities that drive disease in these patients. Patients and Methods Analysis included 3,113 patients who were treated in the Medical Research Council UKALL2003 multicenter randomized trial (NCT00222612) between 2003 and 2011. MRD was mea ...
Hereditary artifacts in BRCA1 gene have a significant contributory role in familial cases of breast cancer. However, its germline mutational penetrance in sporadic breast cancer cases with respect to Pakistani population has not yet been very well defined. This study was designed to assess the contributory role of germline mutations of this gene in sporadic cases of breast cancer. 150 cases of unilateral breast cancer patients, with no prior family history of breast cancer and no other disorders ...
There is a high incidence of Niemann-Pick type B disease in the Maghreb region of North Africa, which includes Morocco, Algeria and Tunisia. A hypothesis that there may well be a common, predominant mutant acid sphingomyelinase allele responsible for the type B phenotype in this population has been tested. A deletion of an arginine codon at amino acid residue 608 was found in one patient. The same mutation was also observed in another of our cases. An original screening procedure using 3′end d ...
OBJECTIVE The authors examined whether there is empirical support for the notion that medical patients are upset by being asked questions about psychiatric disorders. METHOD Six hundred and one patients attending a primary care clinic completed the SCREENER-a newly developed, brief self-administered questionnaire that surveys a broad range of psychopathology. In addition, they completed a second questionnaire that assessed their attitudes toward the SCREENER. RESULTS We found a high level of ...
The purpose of this study is to report a successful twin pregnancy and delivery in a female patient with X-linked dominant incontinentia pigmenti (IP) who underwent assisted reproductive technology followed by preimplantation genetic screening (PGS). A 29-year-old female with IP had a previous history of recurrent spontaneous abortion. A molecular analysis revealed the patient had a de novo mutation, 1308_1309insCCCCTTG(p.Ala438ProfsTer26), in the inhibitor of the kappa B kinase gamma gene locat ...
Colorectal cancer (CRC) is the third most deadly cancer in the USA. CRC screening is the most effective way to prevent CRC death, but compliance with recommended screenings is very low. In this study, we investigate whether CRC screening behavior changed under state mandated private insurance coverage of CRC screening in a sample of insured adults from the 1997 to 2008 Behavioral Risk Factor Surveillance Survey (BRFSS). We present difference-in-difference-in-differences (DDD) estimates that comp ...